What question did this study set out to answer?

To determine whether high concentrations of dl-3-hydroxybutyrate protect against myocardial infarction and apoptosis following prolonged fasting and ischemia-reperfusion in rats.

November 1, 2002AJP Heart and Circulatory Physiology

dl-3-Hydroxybutyrate administration prevents myocardial damage after coronary occlusion in rat hearts

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Authors

ZZZou ZhitianFirst Affiliated Hospital of Jiamusi University SSShiro SasaguriKōchi University RKRajesh KatareUniversity of Otago

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Implication

Animal experiment demonstrates that dl-3-hydroxybutyrate reduces infarct size in fasted rats, indicating ketone supplementation protects ischemic myocardium.

Key Points

To determine whether high concentrations of dl-3-hydroxybutyrate protect against myocardial infarction and apoptosis following prolonged fasting and ischemia-reperfusion in rats.
Wistar rats were categorized into four groups based on nutritional state (fed vs. fasted) and treatment (with or without intravenous DL-3-HB given 60 minutes prior to occlusion).
All groups were subjected to 30 minutes of left coronary artery occlusion followed by 120 minutes of reperfusion.
Infarct size was assessed by triphenyltetrazolium chloride (TTC) staining, apoptosis by single-stranded DNA staining, and myocardial ATP levels were measured.
Infarct size was significantly reduced to 26 ± 4% in the fasting + DL-3-HB group compared with 72 ± 3% in the fed group, 75 ± 5% in the fed + DL-3-HB group, and 70 ± 5% in the fasting group (P < 0.01).
Subendocardial apoptosis was significantly lower in the fasting + DL-3-HB group (9 ± 2%) compared with the fed (39 ± 6%), fed + DL-3-HB (37 ± 5%), and fasting (34 ± 3%) groups (P < 0.01).
Myocardial ATP levels following 30 minutes of ischemia and 120 minutes of reperfusion were significantly higher in the fasting + DL-3-HB group than in all other groups (P < 0.01).

Cite This Study

Zhitian et al. (2002) studied this question.

synapsesocial.com/papers/6a12e9a28f1bac20a09e85df https://doi.org/10.1152/ajpheart.00250.2002

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Implication

Animal experiment demonstrates that dl-3-hydroxybutyrate reduces infarct size in fasted rats, indicating ketone supplementation protects ischemic myocardium.

dl-3-Hydroxybutyrate administration prevents myocardial damage after coronary occlusion in rat hearts

Discussion

Member takes

Implication

Key Points

Cite This Study

dl-3-Hydroxybutyrate administration prevents myocardial damage after coronary occlusion in rat hearts

Discussion

Member takes

Implication

Key Points

Cite This Study

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