Key result
Regional ischemia induced an early peak increase in interstitial fluid ATP to 373 +/- 73 nM compared to 38 +/- 8 nM at baseline, and postinfarcted hearts showed a reduced catabolism rate.
Absolute Event Rate: 373% vs 38%
Myocardial ischemia significantly increases interstitial ATP levels, and post-infarction hearts exhibit reduced rates of extracellular adenine nucleotide catabolism.
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Interstitial ATP estimates in rat hearts remain preliminary; leaves open translation to human postinfarct ischemia.
Kuzmin et al. (1998) studied Myocardial infarction. Regional ischemia and adenine nucleotide infusion vs. In situ control hearts was evaluated on Interstitial fluid ATP concentration. Regional ischemia induced an early peak increase in interstitial fluid ATP to 373 +/- 73 nM compared to 38 +/- 8 nM at baseline, and postinfarcted hearts showed a reduced catabolism rate.
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