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October 1, 1961American Journal of Physiology-Legacy Content

Myocardial creatine phosphate and nucleotides in anoxic cardiac arrest and recovery

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Why the study?

Does a 45-min period of anoxia followed by resuscitation alter myocardial concentrations of CrP, ATP, and inosine in isolated perfused dog hearts?

Population

Isolated perfused dog hearts

Comparison

45-min period of anoxia followed by partial… vs Control values (baseline before anoxia)

Design

Preclinical

Follow-up

75 minutes (45 min anoxia + 30 min resuscitation)

Authors

EBEllis S. BensonRegions HospitalGEGerald T. EvansUniversity of MinnesotaBHBen E. HallawayUniversity of Minnesota

Discussion

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Implication

Anoxia-induced energetic imbalance in isolated dog hearts should not change practice; leaves open inosine's role in clinical post-ischemic ATP recovery.

Key Points

  • To examine myocardial energy metabolism and nucleotide breakdown during prolonged anoxic cardiac arrest and subsequent resuscitation with oxygenated blood.
  • Utilized an isolated perfused canine heart model subjected to 45 minutes of complete anoxia.
  • Initiated partial resuscitation through 30 minutes of reperfusion with oxygenated blood.
  • Quantified concentrations of creatine phosphate, adenosine triphosphate, and deaminated breakdown products in myocardium and perfusion effluent.
  • Myocardial creatine phosphate and ATP levels decreased after 45 minutes of anoxia; 30 minutes of oxygenated reperfusion restored creatine phosphate near control levels, but ATP concentrations declined further.
  • Levels of deaminated ATP derivatives, primarily inosine, rose in the myocardium and effluent during anoxia and remained elevated after resuscitation.

Structured PICO

Does a 45-min period of anoxia followed by resuscitation alter myocardial concentrations of CrP, ATP, and inosine in isolated perfused dog hearts?

P
Population
Isolated perfused dog hearts
I
Intervention
45-min period of anoxia followed by partial resuscitation by perfusion of oxygenated blood for 30 min
C
Comparator
Control values (baseline before anoxia)
O
Outcome
Myocardial concentrations of creatine phosphate (CrP) and adenosine triphosphate (ATP)surrogate

Anoxia and subsequent resuscitation in isolated dog hearts disrupt the dynamic equilibrium of ATP breakdown and resynthesis, leading to a loss of inosine into extracellular compartments and persistently low ATP levels despite CrP recovery.

Cite This Study

Benson et al. (1961) studied this question.

synapsesocial.com/papers/6a7193ba5671bbf00bc2eb0fhttps://doi.org/10.1152/ajplegacy.1961.201.4.687
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial ATP synthesis and mechanical function following oxygen deficiency1978 · 211 citations
  2. 2ENERGY METABOLISM IN THE REVERSIBLE AND IRREVERSIBLE PHASES OF SEVERE MYOCARDIAL ISCHEMIA1981 · 22 citations
  3. 3Myocardial High-Energy Phosphates and Function under Different Postischemic Conditions2008 · 26 citations
  4. 4High‐energy phosphates metabolism and recovery in reperfused ischaemic hearts1998 · 9 citations
  5. 5Effect of Ischemia and Reoxygenation on Glycolytic Reactions and Adenosinetriphosphate in Heart Muscle1960 · 108 citations