February 1, 1989AJP Heart and Circulatory Physiology
Effects of ATP precursors on ATP and free ADP content and functional recovery of postischemic hearts
Why the study?
Do ATP precursors (adenosine or AICAriboside) improve ATP/ADP content and functional recovery in postischemic rabbit hearts?
Population
Langendorff-perfused rabbit hearts subjected to 20 min of global ischemia (n=24)
Comparison
Reperfusion for 2 h with perfusate containing… vs Reperfusion for 2 h with normal perfusate (n=8)
Design
Preclinical
Follow-up
2 hours
Authors
Discussion
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Member takes
Implication
ATP restoration fails to improve contractility in postischemic hearts; challenges ATP/ADP deficits as the direct cause of stunning.
Structured PICO
Do ATP precursors (adenosine or AICAriboside) improve ATP/ADP content and functional recovery in postischemic rabbit hearts?
P
Population
Langendorff-perfused rabbit hearts subjected to 20 min of global ischemia (n=24)
I
Intervention
Reperfusion for 2 h with perfusate containing 100 mumol/l of ATP precursors (adenosine [n=8] or 5-amino-4-imidazolecarboxamide riboside [AICAriboside] [n=8])
C
Comparator
Reperfusion for 2 h with normal perfusate (n=8)
O
Outcome
Myocardial ATP and free ADP content, and functional recovery (contractility/developed pressure)surrogate
Replenishing ATP and free ADP levels with adenosine does not improve contractility in postischemic hearts, suggesting these deficits are not the direct cause of stunned myocardium.
Cite This Study
Ambrosio et al. (1989) studied this question.