Key result
Early return of systolic function in postischaemic myocardium was not accompanied by a detectable increase in total adenine nucleotide content.
p-value: p=<0.05
In a canine model of ischemia-reperfusion, early recovery of regional myocardial systolic function occurs independently of total adenine nucleotide pool repletion.
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Questions link between adenine nucleotide repletion and early postischemic recovery; leaves open mechanisms and human applicability.
Glower et al. (1987) studied postischaemic myocardium. 5-amino-4-imidazolecarboxamide riboside (AICAriboside) infusion vs. control values was evaluated on segment shortening and adenine nucleotide content (p=<0.05). Early return of systolic function in postischaemic myocardium was not accompanied by a detectable increase in total adenine nucleotide content.
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