Why the study?
Do adenine nucleotide analogues improve myocardial contractile function and restore ATP levels during reperfusion after ischemia in dogs?
Population
Pentobarbital-anesthetized open-chest dogs subjected to 20-min ligation of the left anterior descending…
Comparison
5 mM 8-bromo-5'-AMP, 30 mM N6, 2'… vs Saline infused at 0.1 ml/kg/min in the left…
Design
Preclinical
Follow-up
30 minutes of reperfusion
Authors
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Supports further preclinical testing of adenine nucleotide analogues; leaves open translation to human myocardial reperfusion injury.
Do adenine nucleotide analogues improve myocardial contractile function and restore ATP levels during reperfusion after ischemia in dogs?
8-bromo-AMP improves myocardial contractile recovery and restores ATP levels during reperfusion after ischemia in a canine model.
Nakaï et al. (1996) studied this question.
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