Key result
Adenine nucleotide depletion does not explain myocardial stunning after ischemia.
Why the study?
The contribution of adenine nucleotide depletion to postischaemic myocardial dysfunction ("stunned" myocardium) was unclear.
Does adenine nucleotide depletion account for contractile dysfunction in the stunned myocardium?
Does adenine nucleotide depletion account for contractile dysfunction in the stunned myocardium?
Depletion of adenine nucleotides does not account for contractile dysfunction in a rat model of stunned myocardium.
Does not implicate adenine nucleotide depletion in rat myocardial stunning; leaves open alternative mechanisms for further study.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Zucchi et al. (1990) studied postischaemic myocardial dysfunction ("stunned" myocardium) (n=49). Reperfusion after short term (10 min) ischaemia vs. Prolonged perfusion (up to 180 min) was evaluated on Mechanical function (aortic flow and minute work) and tissue adenine nucleotides. In an isolated rat heart model, depletion of adenine nucleotides did not account for contractile dysfunction in the 'stunned' myocardium.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: