Improvement by 5-Amino-4-Imidazole Carboxamide Riboside of the Contractile Dysfunction That Follows Brief Periods of Ischemia Through Increases in Ecto-5'-Nucleotidase Activity and Adenosine Release in Canine Hearts

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Why the study?

Does AICA riboside improve contractile dysfunction following brief ischemia in a canine model?

Structured PICO

Does AICA riboside improve contractile dysfunction following brief ischemia in a canine model?

Population

49 open-chest dogs subjected to 15 min of occlusion of the left anterior descending coronary artery followed by reperfusion

Intervention

5-Amino-4-imidazole carboxamide (AICA) riboside

Comparator

Untreated group

Outcome

Contractile function assessed by fractional shortening (FS) at 3 h after the onset of reperfusionsurrogate

AICA riboside improves contractile dysfunction following brief ischemia via adenosine-dependent mechanisms in a canine model.

No takes yet. Share an insight, caveat, or question.

Supports AICA riboside for post-ischemic stunning in canines; hypothesis-generating and leaves open human translation.

Kitakaze et al. (1999) studied this question.

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