Key result
In dogs with pacing-induced ischemia, AICA-riboside significantly attenuated the progressive decline in regional wall thickening compared to saline control (31% vs 2% of control; P<0.05).
Why the study?
Does AICA-riboside or nitroglycerin protect against progressive cardiac dysfunction induced by repeated pacing-induced ischemia in a dog model?
Does AICA-riboside or nitroglycerin protect against progressive cardiac dysfunction induced by repeated pacing-induced ischemia in a dog model?
Absolute Event Rate: 31% vs 2%
p-value: p=<0.05
AICA-riboside and nitroglycerin protect against the progressive decline in regional wall motion and subendocardial blood flow caused by sequential periods of ischemia and reperfusion in a dog model.
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Does not support clinical use; leaves open translation of AICA-riboside cardioprotection to human ischemia.
Young et al. (1991) studied pacing-induced ischemia (n=35). AICA-riboside (AICA-r) vs. saline control was evaluated on regional myocardial wall thickening during the sixth pacing period (% of control) (p=<0.05). In dogs with pacing-induced ischemia, AICA-riboside significantly attenuated the progressive decline in regional wall thickening compared to saline control (31% vs 2% of control; P<0.05).
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