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Adaptivity is an important feature of data analysis - the choice of questions to ask about a dataset often depends on previous interactions with the same dataset. However, statistical validity is typically studied in a nonadaptive model, where all questions are specified before the dataset is drawn. Recent work by Dwork et al. (STOC, 2015) and Hardt and Ullman (FOCS, 2014) initiated a general formal study of this problem, and gave the first upper and lower bounds on the achievable generalization error for adaptive data analysis.
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Bassily et al. (2016) studied this question.