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October 1, 1996The Journal of Experimental MedicineOpen Access

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

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Authors

HKHolger KanzlerGoethe University FrankfurtRKRalf KüppersUniversité Claude Bernard Lyon 1MHMartin‐Leo HansmannGoethe University Frankfurt

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Cite This Study

Kanzler et al. (1996) studied this question.

synapsesocial.com/papers/6a12eecb45487b7639a76a4bhttps://doi.org/10.1084/jem.184.4.1495
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.1994 · 105 citations
  2. 2Detection of immunoglobulin heavy‐chain gene rearrangement at the single‐cell level in malignant lymphomas: No rearrangement is found in hodgkin and reed‐sternberg cells1994 · 75 citations