Key result
This review outlines the cardiac and extracardiac factors responsible for cardiac arrhythmogenesis in diabetes and identifies molecular targets for future antiarrhythmic therapy.
This review summarizes the molecular and electrophysiological mechanisms driving cardiac arrhythmias in diabetes and highlights potential therapeutic targets.
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No immediate change to arrhythmia management in diabetes; leaves open validation of identified molecular targets in prospective trials.
Diabetes is a common endocrine disorder with an ever increasing prevalence globally, placing significant burdens on our healthcare systems. It is associated with significant cardiovascular morbidities. One of the mechanisms by which it causes death is increasing the risk of cardiac arrhythmias. The aim of this article is to review the cardiac (ion channel abnormalities, electrophysiological and structural remodelling) and extracardiac factors (neural pathway remodelling) responsible for cardiac arrhythmogenesis in diabetes. It is concluded by an outline of molecular targets for future antiarrhythmic therapy for the diabetic population.
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Tse et al. (2016) conducted a review in Diabetes Mellitus and Cardiac Arrhythmogenesis. This review outlines the cardiac and extracardiac factors responsible for cardiac arrhythmogenesis in diabetes and identifies molecular targets for future antiarrhythmic therapy.
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