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To assess the course of Huntington disease (HD) and the efficacy of therapy for chorea and depression, we used a functional evaluation for 22 HD patients who were followed for 13 to 40 months. Functional capacities of all patients declined notwithstanding the modest therapeutic effects of neuroleptic or antidepressant drugs. The quantitative scale seems applicable to long-term studies.
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Ira Shoulson (1981) studied this question.
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