Key result
In women with peripartum cardiomyopathy, a low baseline left ventricular ejection fraction was associated with a greater incidence of major adverse events.
Why the study?
Does baseline LVEF predict major adverse events in women with peripartum cardiomyopathy?
Observational (n=8,760)
No
Does baseline LVEF predict major adverse events in women with peripartum cardiomyopathy?
Answers are grounded in this paper and cite their sources.
In women with peripartum cardiomyopathy, a baseline LVEF <30% is significantly associated with a higher incidence of major adverse events and poorer recovery of ventricular function.
Background: Peripartum cardiomyopathy (PPCM) is even today an incompletely understood and rare disease affecting pregnant women. There have been few studies from south India, especially Kerala on PPCM.Methods: Women who were referred from Department of Obstetrics and Gynecology from May 2010 to April 2016 for evaluation of dyspnoea during pregnancy or within 5 months of delivery were included in the study. They were screened and women with history suggestive of heart failure during peripartum period were evaluated in detail and followed up.Results: 8760 pregnant and peripartum women presented with dyspnoea out of which 20 patients were diagnosed with PPCM. The incidence of PPCM was 1 per 2190 pregnancies. The mean left ventricular end-diastolic dimension was 58±9 mm, the mean end-systolic dimension 45±6 mm and mean left ventricular ejection fraction (LV EF) 31.45±3.73% at diagnosis. Major adverse events (MAE) occurred in 4 patients. Low baseline ejection fraction (LV EF < 30%) significantly correlated with greater incidence of adverse events.Conclusions: The majority of pregnancy related dyspnoea is benign. Echocardiography can reliably diagnose potentially life threatening conditions and should be performed early. Echocardiography aids in both diagnosis and prognostication in PPCM. Low ejection fraction at baseline (LVEF < 30%) significantly correlates with greater incidence of major adverse events in patients with PPCM.
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Tergestina et al. (2017) conducted an observational in Gestational dyspnoea and peripartum cardiomyopathy (n=8,760). Observational was evaluated on Baseline left ventricular ejection fraction (LVEF) in PPCM patients with vs without major adverse events (p=0.0042). In women with peripartum cardiomyopathy, a low baseline left ventricular ejection fraction was associated with a greater incidence of major adverse events.
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