Key result
Advanced therapies for acute PE evolve rapidly but still lack robust clinical evidence.
Why the study?
Compared to other causes of cardiovascular mortality, there is a substantial paucity of literature informing on advanced therapies in PE despite recent evolution in endovascular treatments and mechanical circulatory support.
This review summarizes the evolving therapeutic landscape for acute pulmonary embolism, including endovascular treatments and mechanical circulatory support.
Limited evidence warrants caution with novel PE therapies; leaves open the need for RCTs to define optimal use.
Therapeutic anticoagulation is the mainstay therapy in acute pulmonary embolism (PE), however, select patients benefit from emergent reperfusion to prevent or rescue acute right ventricular failure and haemodynamic collapse. Compared to other leading causes of cardiovascular mortality such as myocardial infarction and stroke, there is a substantial paucity of literature informing on advanced therapies in PE. Recent years have seen significant evolution in the armamentarium available for PE care with the uptake of several endovascular treatment modalities and increased use of mechanical circulatory support. While several ongoing randomised controlled trials may alter the therapeutic landscape and approach to PE management, at present, we are left with multiple selections with limited guidance. In this review, we discuss the latest therapeutic options available for acute PE and offer an approach to their implementation.
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Yuriditsky et al. (2025) conducted a review in Acute pulmonary embolism. Advanced therapies (thrombolysis, catheter-based therapies, mechanical circulatory support) was evaluated. Advanced therapeutic options for acute pulmonary embolism, including catheter-based therapies and mechanical circulatory support, are rapidly evolving but currently rely on limited robust evidence.
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