The Philadelphia Chromosome and Some Others

Editorials1 October 1964The Philadelphia Chromosome and Some OthersDAVID A. HUNGERFORD, PH.D.DAVID A. HUNGERFORD, PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-789 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe appearance elsewhere in this issue of three papers on chromosome studies in chronic granulocytic leukemia (CGL) has suggested that some sort of stock-taking is in order concerning the present meaningfulness to physicians of this and related kinds of investigation and of some of the possibilities for the future.A minute chromosome, which eventually came to be known as the Philadelphia chromosome and to be abbreviated Ph1(1), has been found to be an abnormality characteristic of some of the hematopoietic cells of the great majority of patients with CGL. Its discovery dates from the early days, July, 1959, according...References1. TOUGHCOURT BROWNBAIKIEBUCKTONHARNDENJACOBSKINGMCBRIDE IWMAGKDGPAMJA: Cytogenetic studies in chronic myeloid leukaemia and acute leukaemia associated with mongolism. Lancet 1: 411, 1961. CrossrefMedlineGoogle Scholar2. NOWELLHUNGERFORD PCDA: Chromosome studies in human leukemia. II. Chronic granulocytic leukemia. J. Nat. Cancer Inst. 27: 1013, 1961. MedlineGoogle Scholar3. RUDKINHUNGERFORDNOWELL GTDAPC: DNA contents of chromosome Ph1 and chromosome 21 in human chronic granulocytic leukemia. Science 144: 1229, 1964. CrossrefMedlineGoogle Scholar4. COURT BROWNTOUGH WMIM: Cytogenetic studies in chronic myeloid leukemia. Advances Cancer Res. 7: 351, 1963. CrossrefMedlineGoogle Scholar5. BOVERI T: The Origin of Malignant Tumors, translated by BOVERI, M., Williams & Wilkins, Baltimore, 1929. Google Scholar6. WALDUPTONJENKINSBORGES NACVKWH: Radiation-induced mouse leukemia: consistent occurrence of an extra and a marker chromosome. Science 143: 810, 1964. CrossrefMedlineGoogle Scholar7. HEYSSELBRILLWOODBURYNISHIMURAGHOSEHOSHINOYAMASAKI RABETETTTM: Leukemia in Hiroshima atomic bomb survivors. Blood 15: 313, 1960. CrossrefMedlineGoogle Scholar8. TANAKAITOKAMADAOKADA NKNK: A case of atomic bomb survivor with chronic granulocytic leukemia in the early stage. J. Kyushu Hemat. Soc. 13: 124, 1963. Google Scholar9. COURT BROWN WM: Observations on possible mechanisms of leukemia induction in man following radiation exposure. Nat. Cancer Inst. Monogr. 14: 291, 1964. MedlineGoogle Scholar10. NICHOLS WW: Relationships of viruses, chromosomes and carcinogenesis. Hereditas 50: 53, 1963. CrossrefGoogle Scholar11. SANDBERGISHIHARACROSSWHITEHAUSCHKA AATLHTS: Comparison of chromosome constitution in chronic myelocytic leukemia and other myeloproliferative disorders. Blood 20: 393, 1962. CrossrefMedlineGoogle Scholar12. TRUJILLOOHNO JMS: Chromosomal alteration of erythropoietic cells in chronic myeloid leukemia. Acta Hemat. 29: 311, 1963. CrossrefMedlineGoogle Scholar13. TOUGHJACOBSCOURT BROWNBAIKIEWILLIAMSON IMPAWMAGER: Cytogenetic studies on bone-marrow in chronic myeloid leukaemia. Lancet 1: 844, 1963. CrossrefMedlineGoogle Scholar14. WHANGFREITJIOCARBONEBRECHER JEJHPPG: The distribution of the Philadelphia chromosome in patients with chronic myelogenous leukemia. Blood 22: 664, 1963. CrossrefMedlineGoogle Scholar15. NOWELL PC: The minute chromosome (Ph1) in chronic granulocytic leukemia. Blut 8: 65, 1962. CrossrefMedlineGoogle Scholar16. LEJEUNETURPINGAUTIER JRM: Le mongolisme, premier exemple d'aberration autosomique humaine. Ann. Génét. 1: 41, 1959. Google Scholar17. CARTERHAMERTONPOLANIGUNALPWELLER COJLPEASD: Chromosome translocation as a cause of familial mongolism. Lancet 2: 678, 1960. CrossrefMedlineGoogle Scholar18. HAMERTONCOWIEGIANNELLIBRIGGSPOLANI JLVAFSMPE: Differential transmission of Down's syndrome (mongolism) through male and female translocation carriers. Lancet 2: 956, 1961. CrossrefMedlineGoogle Scholar19. SHAW MW: Familial mongolism. Cytogenetics 1: 141, 1962. CrossrefMedlineGoogle Scholar20. STERN C: Principles of Human Genetics, Freeman, San Francisco, 1960. Google Scholar21. LINDSTENFRACCAROPOLANIHAMERTONSANGERRACE JMPEJLRRR: Evidence that the Xg blood group genes are on the short arm of the X chromosome. Nature (London) 197: 648, 1963. CrossrefMedlineGoogle Scholar22. RUSSELL LB: Another look at the single-active-X hypothesis. Trans. NY Acad. Sci., Ser. II, 26: 726, 1964. CrossrefMedlineGoogle Scholar23. GARTLERWAXMANGIBLETT SMSHE: An XX/XY human hermaphrodite resulting from double fertilization. Proc. Nat. Acad. Sci. USA 48: 332, 1962. CrossrefMedlineGoogle Scholar24. TURPINLEJEUNELAFOURCADECHIGOTSALMON RJJPC: Presomption de monozygotisme en dépit d'un dimorphisme sexuel: sujet masculin XY et sujet neutre haplo X. C. R. Acad. Sci. (Paris) 252: 2945, 1961. Google Scholar25. WOLFFDE SCHÄRERLEJEUNE EKJ: Contribution à l'étude des jumeaux mongoliens. Un cas de monozygotisme hétérocaryote. Helv. Paediat. Acta 17: 301, 1962. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID A. HUNGERFORD, PH.D.Affiliations: The Institute for Cancer Research Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTranscriptional-Readthrough RNAs Reflect the Phenomenon of "A Gene Contains Gene(s)" or "Gene(s) within a Gene" in the Human Genome, and Thus Are Not Chimeric RNAsIt Is Imperative to Establish a Pellucid Definition of Chimeric RNA and to Clear Up a Lot of Confusion in the Relevant ResearchGlycogen synthase kinase 3β missplicing contributes to leukemia stem cell generationChromosomal Changes in Human Tumors and LeukemiasAspetti citogenetici della leucemia mieloide cronicaDas Philadelphia ChromosomHeredity and Malignancies of The Reticuloendothelial SystemNeuere Ergebnisse der somatischen GenetikChromosomenuntersuchungen bei chronisch-myeloischer Leukämie 1 October 1964Volume 61, Issue 4Page: 789-793KeywordsCellsChromosomesForecasting ePublished: 1 December 2008 Issue Published: 1 October 1964 PDF downloadLoading ...