Key result
Increasing physical activity was strongly inversely associated with risk of total stroke, with a relative risk of 0.66 in the highest versus lowest MET quintile (P for trend=.005).
Why the study?
Does increased physical activity reduce the risk of incident stroke in middle-aged women without prior cardiovascular disease?
Population
72,488 female nurses aged 40 to 65 years without diagnosed cardiovascular disease or cancer at baseline…
Comparison
Higher levels of physical activity measured by… vs Lowest quintile of physical activity.
Design
Cohort
Follow-up
8 years
Authors
Discussion
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Member takes
Implication
Supports activity promotion for stroke prevention in middle-aged women; extends prior CHD associations yet leaves causality open for trials.
Study Design
Type
Cohort (n=72,488)
Multicenter
Yes
Structured PICO
Does increased physical activity reduce the risk of incident stroke in middle-aged women without prior cardiovascular disease?
P
Population
72,488 female nurses aged 40 to 65 years without diagnosed cardiovascular disease or cancer at baseline, residing in 11 US states.
I
Intervention
Higher levels of physical activity measured by metabolic equivalent tasks (METs) in hours per week, including walking.
C
Comparator
Lowest quintile of physical activity.
O
Outcome
Incident stroke occurring between baseline and June 1, 1994.hard clinical
Main Result
Effect estimate: RR 0.66
p-value: p=.005
Moderate-intensity physical activity, such as walking, is associated with a dose-dependent reduction in the risk of total and ischemic stroke in women.
Cite This Study
Frank B. Hu (2000) conducted a cohort in Stroke prevention (n=72,488). Physical activity vs. Lowest MET quintile was evaluated on Incident total stroke (RR 0.66, p=.005). Increasing physical activity was strongly inversely associated with risk of total stroke, with a relative risk of 0.66 in the highest versus lowest MET quintile (P for trend=.005).