Key result
Evidence review outlines case-by-case recommendations for aspirin use in primary prevention and ACS.
Why the study?
Aspirin utilization has been questioned recently by new trials in primary prevention, peripheral vascular disease, stroke, acute coronary syndrome with anticoagulation, and studies suggesting shorter durations.
What are the current indications and recommendations for aspirin use in different clinical scenarios of cardiovascular disease?
What are the current indications and recommendations for aspirin use in different clinical scenarios of cardiovascular disease?
This review summarizes the evolving role of aspirin in cardiovascular disease management, highlighting scenarios where its use is being questioned or modified, such as shorter dual antiplatelet therapy regimens.
Answers are grounded in this paper and cite their sources.
Informs case-by-case aspirin decisions in CVD; extends evidence synthesis but leaves optimal regimens open for new trials.
Background: Acetylsalicylic acid, or aspirin, is one of pharmacological tools most widely used in the care of cardiovascular patients. For years, it has been widely used in primary and secondary prevention to reduce cardiovascular risk. Aspirin utilization has been questioned in recent times, with new trials in different scenarios of cardiovascular disease, such as peripheral vascular disease, stroke, primary prevention in the context of modern medical treatment, or in patients with acute coronary syndrome and concomitant need for anticoagulation. In turn, new studies question the need to maintain aspirin for 12 months together with a thienopyridine after an acute coronary syndrome, suggesting shorter regimens. In this review, we evaluate the evidence behind the current indications for aspirin use in different clinical scenarios and provide recommendations on a case-by-case basis.
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Sigal et al. (2022) conducted a review in Cardiovascular disease. Aspirin was evaluated. Aspirin use in various cardiovascular scenarios, including primary prevention and acute coronary syndrome, is evaluated to provide case-by-case recommendations based on current evidence.
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