Key result
Chronic intermittent hypoxia significantly delayed triglyceride-rich lipoprotein clearance (AUC 461.7 vs 260.0 mmol×h) and induced a 5-fold decrease in adipose lipoprotein lipase activity in mice.
Why the study?
Does chronic intermittent hypoxia inhibit clearance of triglyceride-rich lipoproteins and inactivate adipose lipoprotein lipase in a mouse model of sleep apnoea?
Population
Male C57BL/6J mice on high-cholesterol diet
Comparison
Chronic intermittent hypoxia for 4 weeks vs Chronic intermittent air (control) for 4 weeks
Design
Preclinical
Follow-up
4 weeks
Authors
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Should not yet alter sleep apnea management; leaves open mechanistic contribution of intermittent hypoxia to human dyslipidemia.
Does chronic intermittent hypoxia inhibit clearance of triglyceride-rich lipoproteins and inactivate adipose lipoprotein lipase in a mouse model of sleep apnoea?
Absolute Event Rate: 461.7% vs 260%
p-value: p=0.035
Chronic intermittent hypoxia, a hallmark of sleep apnea, decreases triglyceride-rich lipoprotein clearance and inhibits lipoprotein lipase activity in adipose tissue, potentially contributing to atherogenesis.
Drager et al. (2011) studied Obstructive sleep apnoea (mouse model) (n=79). Chronic intermittent hypoxia (CIH) vs. Chronic intermittent air (CIA) was evaluated on Area under the curve for retinyl esters (REs) concentrations (mmol × h) (p=0.035). Chronic intermittent hypoxia significantly delayed triglyceride-rich lipoprotein clearance (AUC 461.7 vs 260.0 mmol×h) and induced a 5-fold decrease in adipose lipoprotein lipase activity in mice.
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