May 10, 2006AJP Endocrinology and Metabolism
Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction
Why the study?
Does acute cardiac-specific deletion of lipoprotein lipase cause dyslipidemia and cardiac dysfunction in adult mice?
Population
8-week-old MerCreMer (MCM)/Lpl(flox/flox) mice
Comparison
Cardiac-specific loss of lipoprotein lipase… vs Tamoxifen treatment of Lpl mice
Design
Preclinical
Follow-up
Up to 4 weeks after tamoxifen treatment
Authors
Discussion
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Member takes
Implication
Indicates cardiac LPL maintains lipid balance and ventricular function in adult mice; leaves open its role in human metabolic cardiomyopathy.
Structured PICO
Does acute cardiac-specific deletion of lipoprotein lipase cause dyslipidemia and cardiac dysfunction in adult mice?
P
Population
8-week-old MerCreMer (MCM)/Lpl(flox/flox) mice
I
Intervention
Cardiac-specific loss of lipoprotein lipase (LPL) induced by a 2-week tamoxifen treatment
C
Comparator
Tamoxifen treatment of Lpl(flox/flox) mice (control group without LPL deletion)
O
Outcome
Triglyceride levels, gene expression (carnitine palmitoyl transferase I, pyruvate dehydrogenase kinase 4, atrial natriuretic factor), and cardiac dysfunction (ejection fraction)surrogate
Acute cardiac-specific deletion of lipoprotein lipase in adult mice leads to rapid hypertriglyceridemia, altered metabolic gene expression, and cardiac dysfunction.
Cite This Study
Noh et al. (2006) studied this question.