Cyclic AMP

G A Robinson; R.W. Butcher; Earl W. Sutherland

doi:10.1146/annurev.bi.37.070168.001053

June 1, 1968Annual Review of Biochemistry

Cyclic AMP

View at Publisher

Ask AI

Bookmark

Share

Key Points

To review the role of cyclic AMP signaling in modulating the evolutionarily conserved Hippo pathway during cell growth and organ development.
Synthesis of molecular and genetic evidence examining Hippo pathway dynamics originating from Drosophila melanogaster to mammalian systems.
Evaluation of biochemical crosstalk between cyclic AMP secondary messenger signaling and downstream Hippo effectors.
Cyclic AMP serves as a key upstream signal that regulates core Hippo kinase cascade activation.
Crosstalk between cyclic AMP and Hippo effectors coordinates cell proliferation, fate specification, and overall organ size boundaries.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Narrative review outlines cyclic AMP interactions with the Hippo pathway in tissue regulation, highlighting molecular mechanisms controlling organ size and cell fate.

Abstract

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Robinson et al. (1968) studied this question.

synapsesocial.com/papers/6a13099583732aa7db9ec780 https://doi.org/10.1146/annurev.bi.37.070168.001053

View at Publisher

Ask AI

Bookmark

Share

Cyclic AMP

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Cyclic AMP

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading