What question did this study set out to answer?

To evaluate temporal associations between hot flashes and depressed mood, as well as their relationships with reproductive hormone dynamics during the transition to menopause.

June 30, 2009Menopause The Journal of The North American Menopause SocietyOpen Access

Temporal associations of hot flashes and depression in the transition to menopause

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Authors

EFEllen W. FreemanCornell University MSMary D. SammelColorado School of Public Health HLHui LinHangzhou Wanxiang Polytechnic

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Implication

Cohort study reveals depressed mood frequently precedes hot flashes during the menopausal transition, suggesting reproductive hormone fluctuations drive both conditions.

Key Points

To evaluate temporal associations between hot flashes and depressed mood, as well as their relationships with reproductive hormone dynamics during the transition to menopause.
Conducted a 10-year follow-up in a population-based cohort of women who had no experience of hot flashes or depressed mood at baseline.
Over the 10-year follow-up, 67% of women experienced hot flashes, 50% experienced depressed mood, and 41% experienced both symptoms, representing co-occurrence greater than expected by chance (P < 0.001).
Among women who experienced both symptoms, depressed mood was significantly more likely to precede hot flashes (relative risk = 2.1; 95% CI, 1.5–2.9).
Follicle-stimulating hormone increases and inhibin B decreases remained significantly associated with hot flashes in multivariable models (P < 0.001), while within-woman follicle-stimulating hormone increases were linked to depressed mood onset in unadjusted analysis (P = 0.05).

Cite This Study

Freeman et al. (2009) studied this question.

synapsesocial.com/papers/6a130a3ec031bb6829a7c2bc https://doi.org/10.1097/gme.0b013e3181967e16

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Implication

Cohort study reveals depressed mood frequently precedes hot flashes during the menopausal transition, suggesting reproductive hormone fluctuations drive both conditions.

Temporal associations of hot flashes and depression in the transition to menopause

Discussion

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Implication

Key Points

Cite This Study

Temporal associations of hot flashes and depression in the transition to menopause

Discussion

Member takes

Implication

Key Points

Cite This Study

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