Female sex (OR 2.46; 95% CI 1.47-4.13), BMI, pulse pressure, and carotid intima-media thickness were independent predictors of LVDD-PEF in a community-dwelling elderly population.
Cross-Sectional (n=1,568)
No
Female sex, higher BMI, increased pulse pressure, and greater carotid intima-media thickness, along with specific DNA methylation patterns, are associated with left ventricular diastolic dysfunction with preserved ejection fraction in elderly Chinese individuals.
Estimación del efecto: OR 2.46 (95% CI 1.47-4.13)
Tasa de eventos absoluta: 15% vs 6.5%
valor p: p=<0.001
Purpose: Left ventricular diastolic dysfunction with preserved ejection fraction (LVDD-PEF) is an early-stage manifestation but poorly understood in the process of heart failure. This study was designed to investigate risk factors and epigenetic markers for predicting LVDD-PEF. Patients and methods: A community-based study in 1568 residents over 65 years was conducted in Shanghai, People’s Republic of China, from June 2014 to August 2015. Echocardiography was performed to diagnose LVDD-PEF. DNA methylation by whole-genome bisulfite sequencing was used to determine those potential epigenetic markers contributing to LVDD-PEF. Results: A total of 177 participants (11.3%) were diagnosed with LVDD-PEF, and higher prevalence in females than in males (15.0% vs 6.5%, P <0.001). Multivariate logistic regression analysis indicated that female sex (OR 2.46, 95% CI 1.47–4.13), body mass index (BMI) (OR 1.09, 95% CI 1.04–1.14), pulse pressure (PP) (OR 1.03, 95% CI 1.01–1.05) and carotid intima-media thickness (CIMT) (OR 4.20, 95% CI 1.40–12.55) showed a significant association with LVDD-PEF. Overall, 638 CpG sites were differentially methylated in LVDD-PEF group compared to non-LVDD-PEF group ( P <0.001); 242 sites were significantly hypermethylated (covering 238 genes) and 396 sites were significantly hypomethylated (covering 265 genes). Conclusion: Our findings found female, BMI, PP, and CIMT were independent predictors for LVDD-PEF in the community-dwelling elderly population. Regulation of DNA methylation might play a crucial role for LVDD-PEF. Keywords: left ventricular diastolic dysfunction, DNA methylation, risk factor
Wang et al. (Tue,) conducted a cross-sectional in Left ventricular diastolic dysfunction with preserved ejection fraction (LVDD-PEF) (n=1,568). Risk factors (female sex, BMI, pulse pressure, carotid intima-media thickness) and epigenetic markers vs. Males / lower risk factor levels was evaluated on Presence of LVDD-PEF (OR 2.46, 95% CI 1.47-4.13, p=<0.001). Female sex (OR 2.46; 95% CI 1.47-4.13), BMI, pulse pressure, and carotid intima-media thickness were independent predictors of LVDD-PEF in a community-dwelling elderly population.
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