Why the study?
Does aliskiren improve blood pressure control and cardiovascular/renal outcomes in patients with hypertension?
Does aliskiren improve blood pressure control and cardiovascular/renal outcomes in patients with hypertension?
Aliskiren is a promising direct renin inhibitor for hypertension, with ongoing trials expected to elucidate its full cardiovascular and renal benefits.
Answers are grounded in this paper and cite their sources.
Aliskiren may support hypertension management as a direct renin inhibitor; leaves open cardiovascular and renal outcome benefits pending large trials.
IMPORTANCE OF THE FIELD: Aliskiren, a drug which inhibits the initial and rate-limiting step of the renin angiotensin aldosterone system (RAAS), recently approved for the treatment of hypertension, may become a reasonable therapeutic choice in a broad number of clinical conditions sharing an increased cardiovascular risk, where the inhibition of the RAAS has been shown to be beneficial. AREAS COVERED IN THIS REVIEW: The present review summarizes the pharmacokinetic and pharmacodynamic properties of aliskiren along with the clinical trials that took into account the effects of aliskiren on blood pressure control and on a number of renal and cardiovascular end points. The specific effects of aliskiren on different populations (e.g., elderly hypertensives, patients with diabetes and hypertension, patients with hypertension and renal impairment) are discussed. WHAT THE READER WILL GAIN: The review discusses the most recent discoveries of the cardiovascular and renal effects of aliskiren, including a comprehensive discussion of the ongoing trials and of the areas of remaining uncertainty. TAKE HOME MESSAGE: Aliskiren is a promising drug that may become a convenient choice in several clinical conditions. The full spectrum of the beneficial effects of aliskiren will be fully elucidated when the results of the large ongoing trials become available.
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Reboldi et al. (2010) conducted a review in Hypertension. Aliskiren was evaluated. Aliskiren is a promising renin angiotensin aldosterone system inhibitor for hypertension, though its full spectrum of cardiovascular and renal benefits awaits results from large ongoing trials.
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