Key result
ACE inhibition with captopril attenuated the natriuretic and diuretic responses to furosemide by approximately two-thirds and prevented the furosemide-induced rise in heart rate in conscious lambs.
Why the study?
Does captopril alter the cardiovascular, renal, and endocrine responses to furosemide in newborn lambs?
Does captopril alter the cardiovascular, renal, and endocrine responses to furosemide in newborn lambs?
ACE inhibition significantly alters the cardiovascular, renal, and endocrine responses to furosemide in newborn lambs, notably attenuating its diuretic and natriuretic effects.
Answers are grounded in this paper and cite their sources.
May warrant caution with ACE inhibitors plus furosemide in neonates; animal data leaves open human translation.
To test the hypothesis that angiotensin II modulates the physiological responses to furosemide in the newborn, various parameters of cardiovascular, renal, and endocrine function were measured before and after iv injection of furosemide to eight conscious, chronically instrumented lambs in the presence and absence of the angiotensin converting enzyme (ACE) inhibitor, captopril. During ACE inhibition, the rise in heart rate and decrease in renal blood flow in response to furosemide did not occur, and the natriuretic and diuretic responses to furosemide were attenuated by approximately two-thirds. There was also an increase in the urinary excretion of prostaglandin F2 and prostaglandin F1 alpha as well as an increase in the excretion of prostaglandin E2 after furosemide, in the presence of ACE inhibition. Therefore, the cardiovascular, renal, and endocrine responses to furosemide in conscious lambs were significantly altered by ACE inhibition.
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Wildt et al. (1997) studied Healthy animal model (n=8). Captopril (ACE inhibitor) + Furosemide vs. Furosemide alone was evaluated on Cardiovascular, renal, and endocrine function parameters. ACE inhibition with captopril attenuated the natriuretic and diuretic responses to furosemide by approximately two-thirds and prevented the furosemide-induced rise in heart rate in conscious lambs.
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