February 1, 1983AJP Regulatory Integrative and Comparative Physiology

Renal and adrenal responses to converting-enzyme inhibition in fetal and newborn life

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Population

39 animals: 27 chronically catheterized sheep fetuses and 12 newborn lambs

Design

Preclinical

Authors

JRJ RobillardKurume University DWD WeismannUniversity of Würzburg RGR. Ariel GómezCedars-Sinai Medical Center

Discussion

Member takes

Implication

Supports gestational RAS maturation in ovine models; hypothesis-generating with no clinical translation to neonates.

Structured PICO

Population

39 animals: 27 chronically catheterized sheep fetuses (15 at <120 days gestation, 12 at >130 days gestation) and 12 newborn lambs (8-21 days old)

Intervention

Continuous infusion of captopril

Outcome

Renal and adrenal responses including renal blood flow, renal vascular resistance, filtration fraction, blood pressure, plasma renin activity, and plasma aldosterone concentrationsurrogate

The renin-angiotensin system appears to have greater physiological significance in regulating renal vascular resistance and aldosterone secretion in near-term fetuses and postnatally compared to early gestation.

Cite This Study

Robillard et al. (1983) studied this question.

synapsesocial.com/papers/6a8730aec026610cc182da68 https://doi.org/10.1152/ajpregu.1983.244.2.r249

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Renal and adrenal responses to converting-enzyme inhibition in fetal and newborn life

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Renal and adrenal responses to converting-enzyme inhibition in fetal and newborn life

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider