Key result
The kidney plays a dual role as both a target organ and a causative factor in hypertension, involving mechanisms like the renin-angiotensin system and glomerular hemodynamics.
This review highlights the kidney's dual role as a cause and target of hypertension, emphasizing that ACE inhibitors offer pressure-independent renoprotection.
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Should not change ACE inhibitor use in hypertension; leaves open renal mechanisms for prospective trials.
The kidney is important not only as a target organ of hypertension but also as a organ that may cause hypertension. For many years, we have studied basic and clinical aspects of the role of the kidney in hypertension, including the renin-angiotensin, kallikrein-kinin, and prostaglandin systems, glomerular hemodynamics, therapeutic modalities, and prognosis. This review summarizes some of our results together with those of other relevant studies in the literature.
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Abe et al. (1997) conducted a review in Hypertension. The kidney plays a dual role as both a target organ and a causative factor in hypertension, involving mechanisms like the renin-angiotensin system and glomerular hemodynamics.
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