Key result
Alternative pathways, particularly chymase, are responsible for ACE-independent Angiotensin II formation in human tissues and are involved in cardiovascular remodeling.
Understanding ACE-independent Ang II formation, particularly via chymase in the human heart, highlights potential new therapeutic targets for preventing cardiovascular remodeling.
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May identify chymase as a target in remodeling; leaves open whether inhibition improves outcomes.
Uehara et al. (2013) conducted a review in Cardiovascular remodeling. Alternative pathways, particularly chymase, are responsible for ACE-independent Angiotensin II formation in human tissues and are involved in cardiovascular remodeling.
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