Key result
Metabolic syndrome was associated with impaired cardiac autonomic function, with 62% of patients exhibiting abnormal heart rate turbulence indices compared to 27% of controls.
Why the study?
Does metabolic syndrome impair heart rate turbulence in patients without overt cardiac disease?
Case-Control (n=74)
Does metabolic syndrome impair heart rate turbulence in patients without overt cardiac disease?
Metabolic syndrome is associated with impaired cardiac autonomic function, as evidenced by abnormal heart rate turbulence indices, even before overt cardiovascular disease develops.
Highlights potential early autonomic impairment in metabolic syndrome; hypothesis-generating pending prospective validation.
Background: Metabolic syndrome is a cluster of risk factors leading to cardiometabolic diseases. The association between metabolic syndrome and cardiovascular disease (CVD) has been evaluated previously, but none of those studies looked at cardiac autonomic functions in these patients. The aim of the present study was to investigate the effect of metabolic syndrome on heart rate turbulence, which plays an important role in the development of CVD. Methods: Thirty-seven patients (17 females and 20 males) were included in the metabolic syndrome group and 37 subjects (19 females and 18 males) were included in the control group. Heart rate turbulence (HRT) indices [turbulence onset (TO) and turbulence slope (TS)] were calculated from 24-hr ambulatory electocardiographic recordings. Results: At least one of the TO or TS values were within the abnormal range in 62% of the patients within the metabolic syndrome group. In the control group, at least one of the TO or TS values were within the abnormal range in 27% of the subjects. Conclusions: Our study results indicate that cardiac autonomic function is impaired even in the absence of overt cardiac disease in patients with metabolic syndrome. Further studies are needed to elucidate the prognostic significance and clinical implications of impaired autonomic functions in patients with metabolic syndrome.
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Yılmaz et al. (2013) conducted a case-control in Metabolic syndrome (n=74). Metabolic syndrome vs. Control group was evaluated on At least one of the turbulence onset (TO) or turbulence slope (TS) values within the abnormal range. Metabolic syndrome was associated with impaired cardiac autonomic function, with 62% of patients exhibiting abnormal heart rate turbulence indices compared to 27% of controls.
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