Key result
One-year antihypertensive therapy linked to improved HRV in hypertensive patients with metabolic syndrome.
Why the study?
High cardiovascular risk is associated with autonomic nervous system dysfunction, but the effects of antihypertensive treatment on heart rate variability in hypertension based on the cooccurrence of metabolic syndrome required assessment.
Does antihypertensive treatment improve heart rate variability in patients with uncontrolled hypertension and metabolic syndrome?
Population
118 patients with uncontrolled HTN (70 with MetS)
Comparison
Patients with MetS vs patients without MetS receiving antihypertensive treatment
Follow-up
12 months
Authors
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May support autonomic benefits of antihypertensives in metabolic syndrome hypertension; hypothesis-generating, requiring randomized confirmation.
Observational (n=118)
Does antihypertensive treatment improve heart rate variability in patients with uncontrolled hypertension and metabolic syndrome?
p-value: p=<0.05
Antihypertensive treatment significantly improves autonomic balance, as measured by heart rate variability, particularly in hypertensive patients with concurrent metabolic syndrome.
Maciorowska et al. (2020) conducted an observational in Hypertension with or without metabolic syndrome (n=118). Antihypertensive treatment vs. Patients without metabolic syndrome (MetS[-]) was evaluated on Heart rate variability (HRV) indices (SDNN, rMSSD, pNN50, LF, HF, TP, LF/HF ratio) (p=<0.05). A 12-month antihypertensive treatment significantly improved heart rate variability parameters (SDNN, rMSSD, pNN50, and TP) in hypertensive patients with metabolic syndrome (p<0.05).
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