What question did this study set out to answer?

This study aims to explore the relationship between cardiac autonomic control and the severity of essential hypertension in patients on long-term treatment.

September 24, 2001Clinical Physiology

Heart rate variability and its determinants in patients with severe or mild essential hypertension

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Why the study?

Does the severity of essential hypertension correlate with the degree of impairment in heart rate variability among patients on long-term antihypertensive therapy?

Population

Patients with long-term medically treated severe essential hypertension or mild essential hypertension, and…

Comparison

Severe essential hypertension (SEHT) vs Mild essential hypertension and healthy age- and…

Design

Cross-sectional

Authors

HMHanna MussaloKuopio University Hospital EVEsko VanninenUniversity of Helsinki RIRisto IkäheimoOulu University Hospital

Discussion

Member takes

Implication

May signal heightened autonomic risk in severe hypertension; leaves open longitudinal validation for risk stratification in treated patients.

Key Points

This study aims to explore the relationship between cardiac autonomic control and the severity of essential hypertension in patients on long-term treatment.
Compared heart rate variability (HRV) in 34 severe hypertension and 29 mild hypertension patients to healthy controls.
Measured HRV using 10 min ECG during paced breathing, focusing on time and frequency domain metrics.
Identified clinical determinants of HRV including RR-intervals, age, gender, and blood pressure measurements.
HRV measures (SDNN, total power, LF power, HF power) were significantly lower in severe hypertension patients compared to controls (P<0.05 for all).
No significant differences in HRV measures between mild hypertension patients and controls.
Significant determinants of HRV included age, gender, systolic and diastolic blood pressure, and 24-hour blood pressure variations.

Structured PICO

Does the severity of essential hypertension correlate with the degree of impairment in heart rate variability among patients on long-term antihypertensive therapy?

Population

Patients with long-term medically treated severe essential hypertension (n=34) or mild essential hypertension (n=29), and healthy age- and sex-matched control subjects.

Intervention

Severe essential hypertension (SEHT)

Comparator

Mild essential hypertension (MEHT) and healthy age- and sex-matched controls

Outcome

Heart rate variability (HRV) assessed from 10 min ECG-recordings during paced (0.2 Hz) breathing at rest, expressed as time and frequency domain measuressurrogate

Severe essential hypertension is associated with significant impairment of cardiac autonomic control compared to mild hypertension and healthy controls.

Cite This Study

Mussalo et al. (2001) studied this question.

synapsesocial.com/papers/6a20b974e19207255aa02422 https://doi.org/10.1046/j.1365-2281.2001.00359.x

Topics

Hypertension management

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Implication

May signal heightened autonomic risk in severe hypertension; leaves open longitudinal validation for risk stratification in treated patients.

Heart rate variability and its determinants in patients with severe or mild essential hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Heart rate variability and its determinants in patients with severe or mild essential hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider