Key result
New-onset hypertension in middle-aged men is associated with significantly diminished short-term heart rate variability, including lower heart rate variation during deep breathing (21 vs 26, p=0.03).
Case-Control (n=52)
No
Absolute Event Rate: 21% vs 26%
p-value: p=0.03
New-onset hypertension in middle-aged men is associated with diminished short-term heart rate variability, indicating altered cardiovascular autonomic function.
May signal early autonomic dysfunction in new-onset hypertension; hypothesis-generating for HRV monitoring, requiring prospective validation before clinical use.
BACKGROUND: It has been well established that hypertension is associated with autonomic dysregulation. Studies investigating HRV have established that hypertension is characterized by sympathetic overactivity and or attenuation of parasympathetic modulation of the heart. METHODS: We examined short-term heart rate variability (HRV) as well as conventional indices of cardiovascular autonomic function including heart rate variation during deep breathing (HRVdb), 30: 15 ratio, pressor response to quiet standing and isometric handgrip in 35 male subjects (39 +/- 7 year, mean +/- SD) with new-onset hypertension (resting BP 155 +/- 17/101 +/- 8 mm Hg) and 17 age-matched normotensive men (resting BP: 111 +/- 7/71 +/- 5 mmHg). RESULTS: HRVdb was significantly lower in hypertensives (21 +/- 8) compared to normotensives (mean age 36 +/- 7, P = 0.03). Differences in mean RR were insignificant, logarithm of high-frequency (HF) spectral power of RR intervals was significantly lower in hypertensives compared to normotensives in the supine position (P = 0.02). CONCLUSIONS: Our data suggest that new-onset hypertension is characterized by diminished short-term HRV, possibly due to an increase in cardiovascular sympathovagal balance.
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Pavithran et al. (2008) conducted a case-control in New-onset hypertension (n=52). New-onset hypertension vs. Normotensive controls was evaluated on Heart rate variation during deep breathing (HRVdb) (p=0.03). New-onset hypertension in middle-aged men is associated with significantly diminished short-term heart rate variability, including lower heart rate variation during deep breathing (21 vs 26, p=0.03).
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