Key result
Primary hypertension in young adults was associated with significantly disturbed heart rate variability compared to healthy controls (P<0.001), which improved with beta-blockers or ACE inhibitors.
Why the study?
This study aimed to determine the association between HRV and hypertension in young adult patients, as well as the effect of antihypertensive medications on HRV parameters.
Does treatment with specific antihypertensive medications (ACE-I, BB, CCB) improve heart rate variability in young patients with primary hypertension?
Observational (n=70)
Does treatment with specific antihypertensive medications (ACE-I, BB, CCB) improve heart rate variability in young patients with primary hypertension?
p-value: p=< 0.001
Young patients with primary hypertension exhibit disturbed cardiac autonomic function, which may be improved by treatment with beta-blockers or ACE inhibitors, but not calcium channel blockers.
Disturbed HRV in young primary hypertension may improve with BB or ACEI; hypothesis-generating and should not yet change practice.
Objective: this study aimed to determine the association between HRV and hypertension young adult patients, the effect of antihypertensive medications on HRV parameters was also studied. Subjects and Methods: 70 subjects under age of 40 years were classified into two groups: A- Patients’ group, It included 50 subjected they were classified according to type of antihypertensive medications into 3 subgroups; 1): 20 patients on ACE-I, (2): 15 patients on BB, 3): 15 patients on CCB. B)- Control group included 20 healthy subjects. Pulse rate, BP, ECG, and 24h Holter monitor were used to measure heart rate variability (HRV). Results: high statistical significant difference was found between patients and control according to SDNN rMSSD, pNN50 and LF/HF ratio ( P < 0.001). HRV parameters showed improvement in patient treated by BB and ACE-I, whereas no improvement was seen in patients treated by CCB. Conclusion: disturbed cardiac autonomic function was found in young hypertensive patients, treating such patients with either BB or ACE-I was associated with improvement of such autonomic imbalance.
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Moustafa et al. (2019) conducted an observational in Primary Hypertension (n=70). Primary hypertension vs. Healthy controls was evaluated on Heart rate variability (SDNN, rMSSD, pNN50 and LF/HF ratio) (p=< 0.001). Primary hypertension in young adults was associated with significantly disturbed heart rate variability compared to healthy controls (P<0.001), which improved with beta-blockers or ACE inhibitors.
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