Key result
3D in vitro adipose models outperform traditional 2D and animal platforms for obesity therapeutic screening.
Why the study?
Modelling adipose tissue is essential to understand its pathophysiology and develop treatments, but traditional 2D in vitro and animal models have significant limitations.
3D scaffold-based in vitro models of dysfunctional adipose tissue offer a promising, human-relevant platform for studying obesity-linked comorbidities and screening therapeutics.
May advance preclinical obesity research; leaves open clinical translation of 3D model findings pending validation.
Obesity is a global health crisis characterised by excessive accumulation of adipose tissue (AT). Under obesogenic conditions, this metabolically active tissue undergoes fibrosis and inflammation, leading to obesity-linked comorbidities. Modelling AT is essential for understanding its pathophysiology and developing treatments to protect against metabolic complications. 3D in vitro AT models are promising tools that address the limitations of traditional 2D in vitro models and in vivo animal models, providing enhanced biomimetic and human-relevant platforms. 3D models facilitate the study of AT pathophysiology and therapeutic screening. This review discusses the crucial role of AT in obesity-linked comorbidities, its dynamicity and complexity, and recent advances in engineering 3D scaffold-based in vitro dysfunctional AT models, highlighting potential breakthroughs in metabolic research and beyond.
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Negrini et al. (2024) conducted a review in Obesity. 3D in vitro adipose tissue models vs. 2D in vitro models and in vivo animal models was evaluated. 3D in vitro adipose tissue models provide enhanced biomimetic platforms that address the limitations of traditional 2D and animal models for studying obesity pathophysiology and therapeutic screening.
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