What does this research mean for the field?

ACE-inhibitor therapy improves myocardial energy balance in patients with chronic heart failure, as evidenced by a normalization of LDH isoenzyme patterns and decreased ADP/ATP-carrier concentrations. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 2, 1990European Heart Journal

The effect of ACE inhibition on myocardial energy metabolism

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Why the study?

Does ACE-inhibitor treatment improve myocardial energy metabolism markers in patients with chronic heart failure?

Population

33 patients with chronic heart failure

Design

Cohort

Authors

HSHeinz‐Peter SchultheißUniversidade Federal de Minas Gerais GUGerald UllrichHelios Hospital Schwerin MSM SchindlerUniversity of Freiburg

Discussion

Member takes

Implication

ACE-inhibitors may improve myocardial metabolism in heart failure; hypothesis-generating and requires randomized confirmation.

Structured PICO

Does ACE-inhibitor treatment improve myocardial energy metabolism markers in patients with chronic heart failure?

Population

33 patients with chronic heart failure

Intervention

ACE-inhibitor treatment

Outcome

Changes in LDH 1, LDH 5, and ADP/ATP-carrier concentrationsurrogate

ACE-inhibitor therapy improves myocardial energy balance in chronic heart failure, as evidenced by favorable shifts in LDH isoenzymes and ADP/ATP-carrier concentrations.

Cite This Study

Schultheiß et al. (1990) studied this question.

synapsesocial.com/papers/6a131cbb498151d905de6303 https://doi.org/10.1093/eurheartj/11.suppl_b.116

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The effect of ACE inhibition on myocardial energy metabolism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The effect of ACE inhibition on myocardial energy metabolism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider