What is the clinical evidence from this study?

Study design: Other. Population: Heart failure after myocardial infarction. Intervention: Temocapril vs. Untreated MI rats. Primary outcome: Changes in myocardial intracellular creatine kinase (CK) system, LV remodeling, and function.

What does this research mean for the field?

Treatment with the ACE inhibitor temocapril for 12 weeks significantly attenuates progressive alterations in myocardial energy metabolism, specifically mitochondrial and MB-CK fractions, and improves left ventricular remodeling and function after myocardial infarction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2003Japanese Heart JournalOpen Access

Effects of Angiotensin-converting Enzyme Inhibition on Changes in Left Ventricular Myocardial Creatine Kinase System After Myocardial Infarction: Their Relation to Ventricular Remodeling and Function

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Key result

Temocapril treatment for 12 weeks significantly attenuated alterations in mitochondrial and MB-CK fractions and improved LV remodeling and function compared with untreated rats after MI.

Why the study?

Does temocapril improve the myocardial intracellular creatine kinase system and left ventricular function in rats with heart failure after myocardial infarction?

Population

Rats with heart failure after myocardial infarction (MI) induced by left coronary artery occlusion (n=63)

Comparison

Temocapril 80 mg/L in drinking water for 4 weeks… vs Untreated MI rats and sham-operated normal…

Design

Preclinical, Rats were randomized to either an ACE inhibitor group or placebo…

Follow-up

4 weeks and 12 weeks

Authors

EHEiji HironakaShinshu University MHMinoru HongoUniversity of Central Florida MAMasako AzegamiShinshu University

Discussion

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Implication

Supports ACE inhibition effects on post-MI energy metabolism in rats; leaves open clinical translation to human HF.

Structured PICO

Does temocapril improve the myocardial intracellular creatine kinase system and left ventricular function in rats with heart failure after myocardial infarction?

Population

Rats with heart failure after myocardial infarction (MI) induced by left coronary artery occlusion (n=63)

Intervention

Temocapril 80 mg/L in drinking water for 4 weeks or 12 weeks

Comparator

Untreated MI rats (placebo) and sham-operated normal control rats

Outcome

Changes in the myocardial intracellular creatine kinase (CK) system (total creatine, total CK, CK isoenzymes) in relation to left ventricular (LV) remodeling and functionsurrogate

ACE inhibition with temocapril progressively improves myocardial energy metabolism and attenuates left ventricular remodeling in a rat model of chronic heart failure after myocardial infarction, with benefits most apparent at 12 weeks.

Cite This Study

Hironaka et al. (2003) studied Heart failure after myocardial infarction. Temocapril vs. Untreated MI rats was evaluated on Changes in myocardial intracellular creatine kinase (CK) system, LV remodeling, and function. Temocapril treatment for 12 weeks significantly attenuated alterations in mitochondrial and MB-CK fractions and improved LV remodeling and function compared with untreated rats after MI.

synapsesocial.com/papers/6a131cb7498151d905de6300 https://doi.org/10.1536/jhj.44.537

Topics

Heart failure HFrEF treatment

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Effects of Angiotensin-converting Enzyme Inhibition on Changes in Left Ventricular Myocardial Creatine Kinase System After Myocardial Infarction: Their Relation to Ventricular Remodeling and Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effects of Angiotensin-converting Enzyme Inhibition on Changes in Left Ventricular Myocardial Creatine Kinase System After Myocardial Infarction: Their Relation to Ventricular Remodeling and Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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