October 1, 1994Circulation Research
Endomyocardial gene expression during development of pacing tachycardia-induced heart failure in the dog.
Population
12 dogs with pacing-induced cardiomyopathy
Comparison
Ventricular pacing to induce heart failure vs Baseline state in the same animals
Design
Preclinical
Follow-up
Until onset of clinical heart failure (at least 1 week)
Authors
Discussion
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Implication
ANF and CK-B mRNA upregulation in canine pacing HF warrants no clinical change; leaves open molecular remodeling targets for translational study.
Structured PICO
P
Population
12 dogs with pacing-induced cardiomyopathy
I
Intervention
Ventricular pacing to induce heart failure
C
Comparator
Baseline state in the same animals
O
Outcome
Steady-state levels of mRNAs encoding cardiac proteins and corresponding hemodynamic assessmentssurrogate
In a canine model of pacing-induced heart failure, specific changes in gene expression, such as increases in ANF and CK-B mRNA, occur alongside evolving systolic and diastolic dysfunction.
Cite This Study
Williams et al. (1994) studied this question.