Key result
Treatment of primary aldosteronism with surgery or aldosterone antagonists rapidly and persistently restored normal insulin sensitivity, which was initially lower than in normotensive controls (P<0.01).
Why the study?
Does treatment of primary aldosteronism with surgery or aldosterone antagonists improve insulin sensitivity compared to essential hypertension and normotensive controls?
Cohort (n=396)
No
Does treatment of primary aldosteronism with surgery or aldosterone antagonists improve insulin sensitivity compared to essential hypertension and normotensive controls?
Treatment of primary aldosteronism with surgery or aldosterone antagonists rapidly and persistently restores normal insulin sensitivity, which is impaired at baseline.
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Suggests metabolic benefit of primary aldosteronism treatment; leaves open effects on hard outcomes in randomized trials.
Catena et al. (2006) conducted a cohort in Primary aldosteronism (n=396). Surgical or medical treatment (spironolactone) vs. Essential hypertension and normotensive subjects was evaluated on Short- and long-term changes in glucose tolerance and insulin sensitivity. Treatment of primary aldosteronism with surgery or aldosterone antagonists rapidly and persistently restored normal insulin sensitivity, which was initially lower than in normotensive controls (P<0.01).
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