Key result
Microarray analysis of ~7000 genes in failing human hearts revealed altered expression of cytoskeletal and metabolic genes, including decreased SLIM1 and increased gelsolin, versus nonfailing hearts.
Population
13 human hearts and cardiomyopathic mouse models
Comparison
Gene expression profiling using high-density… vs Nonfailing human hearts
Design
Preclinical
Authors
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Gene expression shifts in failing hearts generate mechanistic hypotheses; requires validation in models before any clinical consideration.
Observational (n=13)
High-density microarray analysis identifies specific alterations in cytoskeletal, metabolic, and stress-related gene expression in failing human hearts, highlighting potential molecular mechanisms of heart failure.
Yang et al. (2000) conducted an observational in Heart failure (n=13). High-density oligonucleotide arrays vs. Nonfailing human hearts was evaluated on Changes in gene and protein expression. Microarray analysis of ~7000 genes in failing human hearts revealed altered expression of cytoskeletal and metabolic genes, including decreased SLIM1 and increased gelsolin, versus nonfailing hearts.
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