What does this research mean for the field?

Long-term administration of endothelin receptor antagonists improves survival and prevents pathological alterations in the expression of classic and functional cardiac genes in the failing myocardium of rats with chronic heart failure. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 20, 2000CirculationOpen Access

Long-Term Endothelin Receptor Antagonist Administration Improves Alterations in Expression of Various Cardiac Genes in Failing Myocardium of Rats With Heart Failure

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Why the study?

Does long-term treatment with endothelin receptor antagonists improve survival and alterations in cardiac gene expression in rats with heart failure?

Population

Rats with chronic heart failure (CHF) and control sham-operated rats

Comparison

BQ-123 (ET receptor antagonist) or SB209670 (ET… vs Saline (vehicle) administered for 3 months

Design

Preclinical

Follow-up

3 months

Authors

SSSatoshi SakaiRyukoku University TMTakashi MiyauchiUniversity of Tsukuba IYIwao YamaguchiCedars-Sinai Medical Center

Discussion

Member takes

Implication

Endothelin antagonists may improve survival in rat CHF models; extends prior preclinical data but leaves open human translation.

Structured PICO

Does long-term treatment with endothelin receptor antagonists improve survival and alterations in cardiac gene expression in rats with heart failure?

Population

Rats with chronic heart failure (CHF) and control sham-operated rats

Intervention

BQ-123 (ET(A) receptor antagonist) or SB209670 (ET(A/B) dual receptor antagonist) administered for 3 months

Comparator

Saline (vehicle) administered for 3 months

Outcome

Survival and changes in gene expression of classic molecular markers (mRNA levels of atrial natriuretic peptide and beta-myosin heavy chain) and functional molecular markerssurrogate

Long-term treatment with endothelin receptor antagonists improves survival and prevents molecular changes in the failing hearts of rats with chronic heart failure.

Cite This Study

Sakai et al. (2000) studied this question.

synapsesocial.com/papers/6a135f8071369867e4937d7d https://doi.org/10.1161/01.cir.101.24.2849

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Long-Term Endothelin Receptor Antagonist Administration Improves Alterations in Expression of Various Cardiac Genes in Failing Myocardium of Rats With Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Long-Term Endothelin Receptor Antagonist Administration Improves Alterations in Expression of Various Cardiac Genes in Failing Myocardium of Rats With Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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