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July 10, 2006Neurology

Delayed orthostatic hypotension

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Key result

Delayed orthostatic hypotension (>3 minutes) occurred in 54% of patients with OH and was associated with milder abnormalities of sympathetic adrenergic function.

Why the study?

What is the prevalence and clinical significance of delayed orthostatic hypotension in patients undergoing tilt table testing?

Population

230 patients undergoing tilt table testing

Design

Cross-sectional

Authors

CGChristopher H. GibbonsLife UniversityRFRoy FreemanBoston University

Discussion

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Implication

May warrant prolonged tilt testing to capture milder sympathetic failure; leaves open prognostic value in autonomic disorders.

Study Design

Type

Observational (n=230)

Structured PICO

What is the prevalence and clinical significance of delayed orthostatic hypotension in patients undergoing tilt table testing?

P
Population
230 patients undergoing tilt table testing
I
Intervention
60 degrees head-up tilt for 45 minutes and standing for 5 minutes
O
Outcome
Prevalence, symptoms, and neurophysiologic features of delayed orthostatic hypotensionsurrogate

Delayed orthostatic hypotension is common (accounting for 54% of OH cases) and appears to represent a mild or early form of sympathetic adrenergic failure.

Cite This Study

Gibbons et al. (2006) conducted an observational in Orthostatic hypotension (n=230). Head-up tilt testing and standing was evaluated on Prevalence of delayed orthostatic hypotension (>3 minutes). Delayed orthostatic hypotension (>3 minutes) occurred in 54% of patients with OH and was associated with milder abnormalities of sympathetic adrenergic function.

synapsesocial.com/papers/6a139366c1194a2af5044bc4https://doi.org/10.1212/01.wnl.0000223828.28215.0b
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Delayed Orthostatic Intolerance1992 · 133 citations
  2. 2Hypotension‐induced vasopressin release distinguishes between pure autonomic failure and multiple system atrophy with autonomic failure1992 · 120 citations
  3. 3Sustained increases in sympathetic outflow during prolonged lower body negative pressure in humans1990 · 60 citations
  4. 4Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans.1985 · 750 citations
  5. 5Cerebral Autoregulation in Orthostatic Intolerance2001 · 59 citations