Enterovirus and parechovirus are frequent causes of childhood infections with diverse clinical presentations, best diagnosed by RT-qPCR, and currently lack specific antiviral treatments.
This review provides a brief overview of enterovirus and parechovirus infections in children, highlighting that RT-qPCR is the optimal diagnostic tool and noting the lack of specific treatments.
UNLABELLED: Enterovirus and parechovirus are a frequent cause of infection in children. This review is an overview of what is known from enterovirus and parechovirus infection in children and contains information about the epidemiology, pathogenesis, clinical presentation, diagnosis, treatment, and prognosis of enterovirus and parechovirus infection in children. CONCLUSIONS: EV and HPeV infections are a frequent cause of infection in childhood. The clinical presentation is diverse. RT-qPCR is the best way to detect an EV or HPeV. Cerebrospinal fluid, blood and feces have the highest sensitivity for detecting an EV or HPeV. There is no treatment for EV and HPeV infections. Two vaccines against EV 71 are just licensed in China and will be available on the private market. Little is known about the prognosis of EV and HPeV infections. WHAT IS KNOWN: •EV and HPeV are a frequent cause of infection in children. What is new: •This review gives a brief overview over EV and HPeV infection in children.
Crom et al. (Sat,) conducted a review in Enterovirus and parechovirus infection. Enterovirus and parechovirus are frequent causes of childhood infections with diverse clinical presentations, best diagnosed by RT-qPCR, and currently lack specific antiviral treatments.