Propranolol Effect on Tremor in Alcoholic Withdrawal

Letters1 August 1975Propranolol Effect on Tremor in Alcoholic WithdrawalDUANE H. ZILM, B.A.SC., M.PHIL., D.I.C., EDWARD M. SELLERS, M.D., PH.D., F.R.C.P.(C), STUART M. MACLEOD, M.D., PH.D., F.R.C.P.(C), NAEEMA DEGANI, M.B.B.S.DUANE H. ZILM, B.A.SC., M.PHIL., D.I.C., EDWARD M. SELLERS, M.D., PH.D., F.R.C.P.(C), STUART M. MACLEOD, M.D., PH.D., F.R.C.P.(C), NAEEMA DEGANI, M.B.B.S.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-2-234 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlcoholic withdrawal tremor frequently appears in chronic alcoholics 6 to 48 hours after the cessation of longterm heavy alcohol consumption (1). The tremor is often sufficiently large to cause an impairment of coordinated motor activity and can be a major source of anxiety for the subject.Oral propranolol has been shown to be effective in decreasing essential, familial, and senile tremors (2), while intravenous injections (5 mg) significantly reduce the tremor of anxious and thyrotoxic subjects (3). Because of the success of propranolol in other pathological states where tremor is a principle part of the syndrome, it was felt that...References1. GROSSLEWISHASTEY MEJ: Acute alcohol withdrawal syndrome, in The Biology of Alcoholism, vol. 3 of Clinical Pathology, edited by KISSIN B, BEGLEITER H. New York, Plenum Press, 1974, p. 191 CrossrefGoogle Scholar2. WINKLERYOUNG GR: Efficacy of chronic propranolol therapy in action tremors of the familial, senile or essential varieties. N Engl J Med 290:984-988, 1974 CrossrefMedlineGoogle Scholar3. MARSDENGIMLETTEMCALLISTER CTR: Effects of β-adrenergic blockade on finger tremor and achilles reflex time in anxious and thyrotoxic patients. Acta Endocrinol 57:353-362, 1968 CrossrefMedlineGoogle Scholar4. SHANDNUCKOLLSOATES DEJ: Plasma propranolol levels in adults with observations in four children. Clin Pharmacol Ther 11:112-120, 1970 CrossrefMedlineGoogle Scholar5. MARSDENMEADOWSLANGE CJG: Effect of speed of muscle contraction on physiological tremor in normal subjects and in patients with thyrotoxicosis and myxoedema. J Neurol Neurosurg Psychiatry 33:776-782, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Clinical Institute Alcohol and Drug Addiction Research Foundation 33 Russell Street Toronto, Ontario, M5S 2S1 CanadaToronto Western Hospital 399 Bathurst Street Toronto, Ontario, M5T 2S8 CanadaDepartments of Pharmacology and Medicine The Institute of Biomedical Engineering University of Toronto Toronto, Ontario Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAn assessment of the utilization of the preclinical rodent model literature in clinical trials of putative therapeutics for the treatment of alcohol use disordersLeitlinienorientierte Behandlung alkoholbezogener StörungenChronic treatment with prazosin or duloxetine lessens concurrent anxiety‐like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety‐related alcohol useEffects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent ratsÉthanolEthanolInvolvement of 5-hydroxytryptamine1A receptors in nicotine-induced tail tremor in ratsPharmacotherapy and Pathophysiology of Alcohol WithdrawalThe Alcohol Withdrawal Syndrome. 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