Key result
Lifestyle changes, medical therapy, and sinus node sparing ablation manage multifactorial inappropriate sinus tachycardia.
Why the study?
The pathogenesis of inappropriate sinus tachycardia is not well understood, and its management remains a clinical challenge with limited efficacy of lifestyle modifications and medical therapy.
This review provides a comprehensive overview of the etiology, pathophysiology, diagnosis, and contemporary management strategies for inappropriate sinus tachycardia.
May guide IST management with current options; leaves open need for randomized comparative trials.
Inappropriate sinus tachycardia (IST) is a clinical syndrome that generally affects young patients and is associated with distressing symptoms. Although the most common symptom is palpitations, it can be accompanied by a myriad of symptoms, including anxiety, dizziness, presyncope, and syncope. The pathogenesis of IST is not well understood and considered multifactorial, with autonomic dysfunction being the central abnormality. IST is a diagnosis of exclusion. Management presents a clinical challenge. The overall efficacy of lifestyle modifications and medical therapy may be limited. Recent advances in catheter and surgical sinus node sparing ablation techniques have led to improvement in outcomes. In addition, increased focus has led to development of multimodality team-based interventions to improve outcomes in this group of patients. In this review, we discuss the mechanistic basis of IST, review current approaches to diagnosis, and outline contemporary therapeutic approaches.
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Ahmed et al. (2022) conducted a review in Inappropriate sinus tachycardia. Inappropriate sinus tachycardia is a clinical syndrome with multifactorial pathogenesis that can be managed through lifestyle modifications, medical therapy, and sinus node sparing ablation techniques.
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