Key result
An integrated mathematical model of the human cardiopulmonary system demonstrated internal consistency when simulating responses to hypercapnia and hypoxia compared to literature data.
A novel integrated mathematical model of the human cardiopulmonary system can consistently simulate physiological responses to hypercapnia and hypoxia.
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Requires external validation before clinical use; leaves open further development of integrated cardiopulmonary models.
Cheng et al. (2016) studied Hypercapnia and hypoxia (simulated). Integrated mathematical model of the human cardiopulmonary system vs. Population-averaged cardiorespiratory data from literature was evaluated on Internal consistency of simulated responses of cardiovascular and respiratory variables. An integrated mathematical model of the human cardiopulmonary system demonstrated internal consistency when simulating responses to hypercapnia and hypoxia compared to literature data.
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