Why the study?
Do overnight fasting and oral potassium salts normalize phenothiazine-induced repolarization abnormalities in psychiatric patients?
Do overnight fasting and oral potassium salts normalize phenothiazine-induced repolarization abnormalities in psychiatric patients?
Phenothiazine-induced T-wave abnormalities can be reversed by overnight fasting or oral potassium supplementation, likely due to changes in the intracellular-extracellular potassium ratio.
May normalize phenothiazine-induced ECG abnormalities via fasting or potassium; hypothesis-generating and should not yet change practice.
Effects of overnight fasting and potassium salts given orally (10 gm) on phenothiazine-induced repolarization abnormalities were evaluated in 100 psychiatric patients. Overnight fasting resulted in complete normalization of the electrocardiograms of 57 patients, while the remainder were corrected by potassium administration. The mean serum potassium level was significantly higher for the group that normalized with fasting alone. These results are explainable by a combined phenothiazine- and glucose-induced increase in the intracellular-extracellular ratio of potassium, an important factor in the genesis of repolarization abnormalities.
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Sergio C. Alvarez-Mena (1973) studied this question.
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