Key result
Coadministration of dabigatran etexilate and digoxin did not significantly alter the pharmacokinetics or pharmacodynamics of either drug, indicating no dose adjustment is needed.
Why the study?
Does coadministration of digoxin alter the pharmacokinetics and pharmacodynamics of dabigatran etexilate in healthy volunteers?
Population
23 healthy volunteers
Comparison
Coadministration of dabigatran etexilate and… vs Dabigatran etexilate alone and digoxin alone
Follow-up
4 days per treatment period
Authors
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Supports coadministration without dose adjustment in healthy volunteers; leaves open confirmation in patients with cardiovascular disease.
Does coadministration of digoxin alter the pharmacokinetics and pharmacodynamics of dabigatran etexilate in healthy volunteers?
Dabigatran etexilate and digoxin can be coadministered without the need for dose adjustment of either drug, as there are no significant pharmacokinetic or pharmacodynamic interactions.
Stangier et al. (2011) studied Healthy volunteers (n=23). Dabigatran etexilate and digoxin coadministration vs. Dabigatran alone and digoxin alone was evaluated on Pharmacokinetics (Cmax,ss and AUCτ,ss) and pharmacodynamics (blood coagulation time). Coadministration of dabigatran etexilate and digoxin did not significantly alter the pharmacokinetics or pharmacodynamics of either drug, indicating no dose adjustment is needed.
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