Key result
Review outlines the pathophysiology, diagnostic work-up, and clinical management of MINOCA subtypes.
Why the study?
Diagnosis and management of myocardial infarction with nonobstructive coronary arteries have been challenging due to its many diverse etiologies.
This review provides a comprehensive overview of the pathophysiology, diagnostic work-up, and clinical management of MINOCA.
Supports structured MINOCA evaluation; leaves open the need for prospective trials on subtype-specific therapies.
Myocardial Infarction with Nonobstructive Coronary Arteries (MINOCA), as the name implies, is an acute myocardial infarction (MI) in the absence of significant coronary artery obstruction. Diagnosis and management of such cases have been challenging. There are many etiologies of MINOCA including coronary artery spasm, coronary microvascular dysfunction, plaque disruption, spontaneous coronary thrombosis or emboli, spontaneous coronary artery dissection, or cardiomyopathies. In this paper, the pathophysiology, diagnostic work-up, and clinical management for each subtype are described, and an overarching approach on how to evaluate and manage a patient presenting with MINOCA.
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Chow et al. (2021) conducted a review in Myocardial Infarction with Nonobstructive Coronary Arteries (MINOCA). This literature review outlines the pathophysiology, diagnostic work-up, and clinical management of MINOCA subtypes, providing an overarching approach for patient evaluation and care.
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