Key result
Patients with rheumatoid arthritis had significantly longer QT dispersion and corrected QT dispersion values compared to healthy controls (p<0.05), especially those with disease duration over 5 years.
Why the study?
Does rheumatoid arthritis increase QT dispersion and alter diastolic function compared to healthy controls?
Cross-Sectional (n=88)
Does rheumatoid arthritis increase QT dispersion and alter diastolic function compared to healthy controls?
p-value: p=<0.05
Rheumatoid arthritis is associated with increased repolarization heterogeneity and diastolic dysfunction, which worsen with longer disease duration.
RA-associated QT dispersion may warrant ECG vigilance in long-duration disease; case-control data leave arrhythmia risk prediction open.
OBJECTIVE: To investigate the dispersion of repolarization variables in patients with rheumatoid arthritis (RA). METHODS: Electrocardiography (ECG) and Doppler echocardiography were performed on 40 patients with RA, which were divided into two groups according to the duration of disease and in 48 healthy controls. RESULTS: All patients had significantly longer QT dispersion (QTd) and corrected QT dispersion (QTc-d) values (p<0.05). The mean values of diastolic function variables were significantly different in all patients compared to healthy controls (p<0.05). There were no statistically significant differences between patient groups in terms of diastolic function variables except IVRT. However, QTd and QTc-d were significantly longer in patients with disease duration over 5 years (p<0.05). CONCLUSION: We conclude that repolarization heterogeneity and diastolic dysfunction are commonly seen in RA, and QTd is significantly longer in those patients with a disease duration over 5 years compared to those with new onset RA.
No takes yet. Share an insight, caveat, or question.
Cindaş et al. (2002) conducted a cross-sectional in Rheumatoid arthritis (n=88). Rheumatoid arthritis vs. Healthy controls was evaluated on QT dispersion (QTd) and corrected QT dispersion (QTc-d) (p=<0.05). Patients with rheumatoid arthritis had significantly longer QT dispersion and corrected QT dispersion values compared to healthy controls (p<0.05), especially those with disease duration over 5 years.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: