Synchronous Lobular Breast Cancer and Lung Adenocarcinoma: Α Case Report

Synchronous breast and lung cancer (SBLC) is a rare entity posing great challenges in diagnosis and treatment. A 58-year-old female was referred to the breast department of our hospital with a palpable mass in the right breast. Mammography, ultrasound, and magnetic resonance (MR) imaging revealed bilateral, multifocal breast lesions. Core needle biopsy (CNB) revealed pleomorphic lobular breast cancer in the right breast and ductal carcinoma in situ (DCIS) in the left breast. Staging positron emission tomography-computed tomography (PET-CT) showed a suspicious lesion in the left lung. CT-guided biopsy revealed lung adenocarcinoma. According to the multidisciplinary team (MDT) decision, the patient underwent a staged approach. First, she was scheduled for bilateral mastectomy and right sentinel lymph node biopsy (SLNB). One month later, she underwent a left upper lobectomy and lymphadenectomy through a left posterior mini-thoracotomy. At present, two years later, the patient is currently in remission. Thus far, there are no clear and unified treatment guidelines for SBLC. Therefore, such cases should be discussed in MDT meetings, taking into account the stage of each cancer, the morbidity and mortality of each therapeutic approach, together with the patient’s comorbidity and preference.